Cytochrome P450 27B1 Gene Polymorphism rs10877012 and rs4646536 in Patients with Systemic Lupus Erythematosus

Systemic lupus erythematosus is a severe inflammatory connective tissue disease induced by autoimmunity. The cytochrome p450 27B1 gene, activating Vitamin D precursor 25-hydroxyvitamin into 1,25-dihydroxyvitamin in immunity cells resulted autoimmune disorders. This study was assessing the correlation and clinical pathological characteristics relationship between gene polymorphism rs10877012/rs4646536 systemic to provide rationale for determining role that plays erythematosus. In this study, we investigated association of rs10877012 (T/G) with susceptibility 156 patients compared healthy population, both groups came from same Mendelian population conformity Hardy Weinberg equilibrium. DNA extracted peripheral leukocytes analyzed using polymerase chain reaction-ligase detection reaction method. We found an presence T allele at polymorphic site (odds ratio=2.94; 95 % confidence interval 1.77–4.86; <0.0001) decreased colorectal cancer incidence. associated arthritis positive Anti-double stranded antibody increased C-reactive protein happened